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廖亚金(Yajin Liao)
汉族,讲师,理学博士(中国科学院生物物理研究所),生物学博士后(中国人民解放军军事医学研究院),现任生命与环境科学学院(转化神经科学中心)教师。
通信地址:北京市海淀区中关村南大街27号金年会体育在线登录生命与环境科学学院
邮编:129871
电子邮箱:lyajin@163.com
讲授课程
免疫学
主要研究内容
神经退行性疾病的理论和应用研究:从天然免疫信号通路和神经炎症入手,以民族药单一组分为药物库,聚焦阿尔兹海默病、缺血性中风和抑郁症等神经退行性疾病的分子机制研究和新药筛选。
主持教学和科研项目
1.2017年:国家自然科学基金青年基金(项目批准号:81701187);
2. 2017年:中国博士后基金面上项目(项目编号:2017M613411);
3. 2019年:现代中医药制剂国家重点实验室开放课题(项目编号:TCM-201914);
4. 2019年:国家卫生健康委出生缺陷研究与预防重点实验室开放课题(项目编号:KF2019001)。
代表作
1.Rui-yuan Pan#, Xiang-xi Kong#, Yong Cheng, Yu-han Yan, Zhen-chao Wang, Chao Yuan, Jin-bo Cheng, Zeng-qiang Yuan, Hai-yan Zhang*, Ya-jin Liao*. 1,2,4-Trimethoxybenzene selectively inhibits NLRP3 inflammasome activation and attenuates experimental autoimmune encephalomyelitis. Acta Pharmacologica Sinica. 2021. (JCR一区)
2.Yajin Liao#, Jinbo Cheng#, Xiangxi Kong#, Shuoshuo Li, Xiaoheng Li, Meijuan Zhang, He Zhang3, Tianli Yang, Yuan Dong, Jun Li, Yun Xu , Zengqiang Yuan. HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. Theranostics. 2020. 10(21):9644-9662.(JCR一区)
3.Yajin Liao#, Yuan Dong#, Jinbo Cheng. The Molecular Determinants of Mitochondrial Membrane Contact with ER, Lysosomes and Peroxisomes in Neuronal Physiology and Pathology. Front Cell Neurosci. 2020. 14(7):00194.(JCR二区)
4.Jinbo Cheng#,Yajin Liao#, Yuan Dong#, Han Hu, Nannan Yang, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Jifeng Guo, Lixia Qin, Jiezhong Yu, Cungen Ma, Jianke Li, Mingtao Li, Beisha Tang, Zengqiang Yuan. Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice. Autophagy. 2020. Jan 31:1-13. (JCR一区,共同一作)
5.Yajin Liao, Yuan Dong, and Jinbo Cheng. The function of the mitochondrial calcium uniporter in neurodegenerative disorders. Int. J. Mol. Sci. 2017. 18(2). pii: E248.(JCR三区)
6.Jinbo Cheng#,Yajin Liao#, Lei Xiao, Shengyi Peng, Yun Xu, Zengqiang Yuan. Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia. Cell death and differ. 2017. 24(2):276-87. (JCR一区,共同一作)
7.Jinghan Wang#, Shucheng Chen#,Yajin Liao#, Enyu Zhang, Shuo Feng, Shaoxiong Yu, Lian-Feng Li, Wen-Rui He, Yongfeng Li, Yuzi Luo, Yuan Sun, Xiao Wang, Muhammad Munir, Su Li, Hua-Ji Qiu. Mitogen-activated protein kinase kinase 2 (MEK2), a novel E2-interacting protein, promotes the growth of classical swine fever virus via attenuation of IFN-JAK-STAT pathway. J Virol. 2016. 90(22):10271-83. (JCR一区,共同一作)
8.Jinbo Cheng#,Yajin Liao#, Lujun Zhou, Shengyi Peng, Hong Chen, Zengqiang Yuan. Amplified RLR signaling activation through an interferon-stimulated gene-endoplasmic reticulum stress-mitochondrial calcium uniporter protein loop.Sci Rep-UK. 2016. 6:20158. (JCR二区,共同一作)
9.Yajin Liao, Yuming Hao, Hong Chen, Qing He, Zengqiang Yuan, Jinbo Cheng. Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death. Protein&Cell. 2015. 6(6):434-42.(JCR三区)
10.廖亚金,李素,贺番,何文瑞,董泓,冯烁,孙元,仇华吉.猪外周血单个核细胞cDNA酵母表达文库的构建及与猪瘟病毒E2蛋白相互作用细胞蛋白的筛选.中国预防兽医学报,2013. 35(9):707-10.(中文核心期刊)